Uncontrolled HIV RNA, immunodeficiency, and malignancy: implications for cancer control.
نویسنده
چکیده
In April 2009, The Lancet Oncology published the findings of a working group (36 scientists from 16 countries) that met in February 2009 at the International Agency for Research on Cancer (Lyon, France) to reassess the carcinogenicity of the biological agents classified as “carcinogenic to humans” (group 1) [1]. With regard to human immunodeficiency virus (HIV) infection, a clear link has been recognized with several oncogenic viruses, mainly Epstein-Barr virus, Kaposi sarcoma herpes virus, and the human papilloma viruses. The epidemiological and mechanistic evidence accumulated worldwide has been considered sufficient to determine that HIV, through an immunosuppressive indirect action, causes Kaposi sarcoma, nonHodgkin lymphoma (NHL), Hodgkin lymphoma, and cancers of the cervix, anus, and conjunctiva. The evidence supporting a causal role of HIV was considered limited for cancers of the vulva, vagina, and penis; for nonmelanoma skin cancer; and for hepatocellular carcinoma. However, for other cancer types (namely
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 49 7 شماره
صفحات -
تاریخ انتشار 2009